%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Eytan Shtull-Leber, Robert Silbergleit, William J. Meurer
Pre-hospital midazolam for benzodiazepine-treated seizures before and after the Rapid Anticonvulsant Medication Prior to Arrival Trial: A national observational cohort study
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 11 0 R/Annots 12 0 R/Contents 13 0 R/TrimBox[0 0 612 792]>>
endobj
12 0 obj
[14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R]
endobj
14 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173539.ref001)>>
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173539.ref002)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173539.ref003)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173539.ref004)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0173539.ref004)>>
endobj
19 0 obj
<>/Border[0 0 0]/A 20 0 R>>
endobj
20 0 obj
<>
endobj
13 0 obj
[21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R]
endobj
21 0 obj
<>stream
q
0.45 0.36 0.35 0.01 k
0 w
575.9997 666.2299 m
199.9998 666.2299 l
199.9998 666.7299 l
575.9997 666.7299 l
f*
0.83 0.64 0.02 0 k
354.274 567.7228 m
358.9795 567.7228 l
h
f*
434.0409 541.7575 m
438.8031 541.7575 l
h
f*
278.4189 515.7354 m
283.1811 515.7354 l
h
f*
321.7323 146.948 m
326.4945 146.948 l
h
f*
323.6598 120.926 m
328.422 120.926 l
h
f*
0 g
1 j
1 J
9.5 0 0 9.5 200.0125 707.7543 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(on)Tj
1.3128 0 Td
(route)Tj
2.4647 0 Td
(of)Tj
1.0443 0 Td
(drug)Tj
2.1901 0 Td
(of)Tj
1.0444 0 Td
(administration.)Tj
6.636 0 Td
(The)Tj
1.9276 0 Td
(safety)Tj
2.8585 0 Td
(and)Tj
1.8619 0 Td
(effectiveness)Tj
5.9915 0 Td
(of)Tj
1.0444 0 Td
(midazolam)Tj
4.9949 0 Td
(for)Tj
1.3725 0 Td
(benzodiaz-)Tj
-34.7436 -1.474 Td
(epine-treated)Tj
6.0392 0 Td
(seizures)Tj
3.8969 0 Td
(in)Tj
0.9847 0 Td
(prehospital)Tj
5.0486 0 Td
(clinical)Tj
3.1688 0 Td
(practice)Tj
3.6821 0 Td
(appear)Tj
3.2941 0 Td
(consistent)Tj
4.6727 0 Td
(with)Tj
1.9753 0 Td
(trial)Tj
1.8082 0 Td
(data,)Tj
2.4169 0 Td
(which)Tj
-36.9875 -1.474 Td
(should)Tj
3.127 0 Td
(encourage)Tj
4.8875 0 Td
(continuing)Tj
4.7145 0 Td
(increases)Tj
4.4459 0 Td
(in)Tj
0.9846 0 Td
(utilization.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 624.8125 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 607.8047 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Second)Tj
3.1237 0 Td
(stage)Tj
2.2054 0 Td
(knowledge)Tj
4.541 0 Td
(translationthe)Tj
6.7068 0 Td
(process)Tj
3.1861 0 Td
(by)Tj
1.1792 0 Td
(which)Tj
2.6532 0 Td
(clinical)Tj
3.0727 0 Td
(trial)Tj
1.8369 0 Td
(findings)Tj
3.4922 0 Td
(move)Tj
2.4265 0 Td
(into)Tj
-34.4237 -1.2982 Td
(accepted)Tj
3.6906 0 Td
(clinical)Tj
3.0728 0 Td
(practicehas)Tj
5.6295 0 Td
(often)Tj
2.2848 0 Td
(been)Tj
2.1203 0 Td
(slow)Tj
2.0182 0 Td
(and)Tj
1.7291 0 Td
(incomplete.)Tj
4.9209 0 Td
(Indeed,)Tj
3.2372 0 Td
(the)Tj
1.4683 0 Td
(Institute)Tj
3.583 0 Td
(of)Tj
1.0148 0 Td
(Medi-)Tj
-34.7695 -1.2983 Td
(cine)Tj
1.8821 0 Td
(reported)Tj
3.6567 0 Td
(an)Tj
1.2076 0 Td
(average)Tj
3.2258 0 Td
(of)Tj
1.0148 0 Td
(17)Tj
1.1678 0 Td
(years)Tj
2.2677 0 Td
(interval)Tj
3.2599 0 Td
(between)Tj
3.5319 0 Td
(reports)Tj
3.0671 0 Td
(of)Tj
1.0148 0 Td
(randomized)Tj
5.0626 0 Td
(controlled)Tj
4.32 0 Td
(trials)Tj
-34.6788 -1.3039 Td
(and)Tj
1.7291 0 Td
(broad)Tj
2.5681 0 Td
(incorporation)Tj
5.7884 0 Td
(into)Tj
1.8368 0 Td
(practice[)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
4.7622 0 Td
(Very)Tj
2.1656 0 Td
(little)Tj
1.9956 0 Td
(is)Tj
0.8504 0 Td
(known)Tj
3.0047 0 Td
(about)Tj
2.4945 0 Td
(knowledge)Tj
4.541 0 Td
(translation)Tj
4.5354 0 Td
(in)Tj
-36.2718 -1.2983 Td
(the)Tj
1.4626 0 Td
(pre-hospital)Tj
5.04 0 Td
(setting,)Tj
3.1011 0 Td
(where)Tj
2.6475 0 Td
(a)Tj
0.652 0 Td
(historical)Tj
3.9174 0 Td
(dearth)Tj
2.8006 0 Td
(of)Tj
1.0092 0 Td
(robust)Tj
2.7892 0 Td
(clinical)Tj
3.0728 0 Td
(trials)Tj
2.194 0 Td
(and)Tj
1.7234 0 Td
(the)Tj
1.4684 0 Td
(multiple)Tj
3.5603 0 Td
(levels)Tj
-35.4385 -1.2982 Td
(of)Tj
1.0147 0 Td
(medical)Tj
3.3619 0 Td
(providers)Tj
4.0195 0 Td
(may)Tj
1.9276 0 Td
(be)Tj
1.1508 0 Td
(barriers)Tj
3.3279 0 Td
(to)Tj
1.0261 0 Td
(change)Tj
3.0387 0 Td
(in)Tj
1.0375 0 Td
(practice[)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(].)Tj
-18.7085 -1.3039 Td
(The)Tj
1.7858 0 Td
(2012)Tj
2.1203 0 Td
(publication)Tj
4.7622 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(results)Tj
2.8062 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(Rapid)Tj
2.5908 0 Td
(Anticonvulsant)Tj
6.3666 0 Td
(Medication)Tj
4.8075 0 Td
(Prior)Tj
2.2961 0 Td
(to)Tj
1.0261 0 Td
(Arrival)Tj
-34.7298 -1.2983 Td
(Trial)Tj
2.1486 0 Td
(\(RAMPART\)[)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(])Tj
6.7294 0 Td
(provides)Tj
3.651 0 Td
(a)Tj
0.652 0 Td
(unique)Tj
3.0217 0 Td
(opportunity)Tj
5.0343 0 Td
(to)Tj
1.0261 0 Td
(examine)Tj
3.6 0 Td
(the)Tj
1.474 0 Td
(effect)Tj
2.3641 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.6519 0 Td
(high-impact)Tj
-31.3679 -1.2983 Td
(factor)Tj
2.5398 0 Td
(journal)Tj
3.1124 0 Td
(on)Tj
1.2756 0 Td
(second)Tj
3.0104 0 Td
(stage)Tj
2.2053 0 Td
(knowledge)Tj
4.5411 0 Td
(translation)Tj
4.5354 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4683 0 Td
(pre-hospital)Tj
5.0457 0 Td
(environment.)Tj
5.6522 0 Td
(RAM-)Tj
-34.418 -1.2982 Td
(PART)Tj
2.6928 0 Td
(was)Tj
1.7008 0 Td
(a)Tj
0.652 0 Td
(large)Tj
2.16 0 Td
(multicenter)Tj
4.8699 0 Td
(randomized)Tj
5.0626 0 Td
(clinical)Tj
3.0727 0 Td
(trial)Tj
1.8369 0 Td
(of)Tj
1.0148 0 Td
(pre-hospital)Tj
5.04 0 Td
(treatment)Tj
4.1385 0 Td
(of)Tj
1.0148 0 Td
(patients)Tj
-33.2558 -1.304 Td
(with)Tj
1.9955 0 Td
(convulsive)Tj
4.4334 0 Td
(status)Tj
2.5001 0 Td
(epilepticus.)Tj
4.7168 0 Td
(The)Tj
1.7859 0 Td
(trial)Tj
1.8368 0 Td
(demonstrated)Tj
5.76 0 Td
(that)Tj
1.7801 0 Td
(intramuscular)Tj
5.8507 0 Td
(midazolam,)Tj
-30.6593 -1.2982 Td
(which)Tj
2.6475 0 Td
(was)Tj
1.7008 0 Td
(increasingly)Tj
5.0286 0 Td
(being)Tj
2.4321 0 Td
(used)Tj
2.0636 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2756 0 Td
(theoretical)Tj
4.439 0 Td
(advantages,)Tj
4.8246 0 Td
(was)Tj
1.7007 0 Td
(superior)Tj
3.566 0 Td
(to)Tj
1.0261 0 Td
(intrave-)Tj
-33.1764 -1.2983 Td
(nous)Tj
2.1656 0 Td
(lorazepam)Tj
4.3823 0 Td
(at)Tj
0.9525 0 Td
(terminating)Tj
4.9606 0 Td
(convulsions)Tj
4.9719 0 Td
(prior)Tj
2.2564 0 Td
(to)Tj
1.0261 0 Td
(emergency)Tj
4.5751 0 Td
(department)Tj
4.8812 0 Td
(arrival)Tj
2.795 0 Td
(without)Tj
3.3335 0 Td
(the)Tj
-36.3002 -1.3039 Td
(need)Tj
2.1429 0 Td
(for)Tj
1.3833 0 Td
(rescue)Tj
2.7553 0 Td
(medication.)Tj
-5.0853 -1.2983 Td
(We)Tj
1.61 0 Td
(therefore)Tj
3.8551 0 Td
(determined)Tj
4.8529 0 Td
(the)Tj
1.4683 0 Td
(changes)Tj
3.4016 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(first-line)Tj
3.6453 0 Td
(use)Tj
1.5307 0 Td
(of)Tj
1.0148 0 Td
(midazolam)Tj
4.6885 0 Td
(for)Tj
1.3833 0 Td
(pre-hospital)Tj
-31.1525 -1.2982 Td
(benzodiazepine-treated)Tj
9.564 0 Td
(seizures)Tj
3.3732 0 Td
(before)Tj
2.7382 0 Td
(and)Tj
1.7292 0 Td
(after)Tj
2.0352 0 Td
(publication)Tj
4.7622 0 Td
(of)Tj
1.0148 0 Td
(RAMPART.)Tj
5.1193 0 Td
(Additionally,)Tj
5.4539 0 Td
(we)Tj
-35.79 -1.3039 Td
(evaluated)Tj
3.9911 0 Td
(the)Tj
1.4683 0 Td
(generalizability)Tj
6.2872 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(RAMPART)Tj
4.8925 0 Td
(findings)Tj
3.4923 0 Td
(by)Tj
1.1849 0 Td
(evaluating)Tj
4.32 0 Td
(the)Tj
1.4683 0 Td
(effectiveness)Tj
5.2044 0 Td
(of)Tj
1.0148 0 Td
(pre-)Tj
-35.807 -1.2983 Td
(hospital)Tj
3.3788 0 Td
(midazolam)Tj
4.6885 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.4683 0 Td
(termination)Tj
5.006 0 Td
(of)Tj
1.0148 0 Td
(prolonged)Tj
4.3313 0 Td
(seizures)Tj
3.3732 0 Td
(in)Tj
1.0318 0 Td
(routine)Tj
3.1635 0 Td
(clinical)Tj
3.0784 0 Td
(practice)Tj
3.3788 0 Td
(on)Tj
1.2756 0 Td
(a)Tj
-36.5723 -1.2983 Td
(national)Tj
3.5035 0 Td
(level.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 345.4299 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Methods)Tj
/F0 1 Tf
0 -1.5023 Td
(Overview)Tj
4.3464 0 Td
(and)Tj
1.8615 0 Td
(setting)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 310.3937 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(This)Tj
1.9842 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.6519 0 Td
(phase)Tj
2.4832 0 Td
(IV,)Tj
1.4797 0 Td
(retrospective,)Tj
5.5898 0 Td
(observational)Tj
5.5786 0 Td
(cohort)Tj
2.8516 0 Td
(study)Tj
2.3924 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(impact)Tj
2.982 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(publication)Tj
4.7622 0 Td
(of)Tj
-36.5723 -1.2982 Td
(the)Tj
1.4683 0 Td
(RAMPART)Tj
4.8926 0 Td
(results)Tj
2.8119 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(pre-hospital)Tj
5.04 0 Td
(use)Tj
1.5307 0 Td
(of)Tj
1.0148 0 Td
(midazolam)Tj
4.6885 0 Td
(for)Tj
1.3889 0 Td
(benzodiazepine-treated)Tj
9.5697 0 Td
(sei-)Tj
-35.1493 -1.2983 Td
(zures.)Tj
2.5398 0 Td
(Since)Tj
2.3584 0 Td
(the)Tj
1.4683 0 Td
(duration)Tj
3.702 0 Td
(between)Tj
3.532 0 Td
(911)Tj
1.6441 0 Td
(call)Tj
1.5704 0 Td
(and)Tj
1.7291 0 Td
(EMS)Tj
2.16 0 Td
(arrival)Tj
2.8006 0 Td
(is)Tj
0.8447 0 Td
(almost)Tj
2.8857 0 Td
(universally)Tj
4.558 0 Td
(greater)Tj
3.0047 0 Td
(than)Tj
-34.7978 -1.3039 Td
(five)Tj
1.6497 0 Td
(minutes)Tj
3.4696 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(United)Tj
3.0217 0 Td
(States,)Tj
2.7326 0 Td
(we)Tj
1.3266 0 Td
(used)Tj
2.0636 0 Td
(the)Tj
1.4683 0 Td
(presence)Tj
3.7134 0 Td
(of)Tj
1.0148 0 Td
(benzodiazepine)Tj
6.4403 0 Td
(treatment)Tj
4.1329 0 Td
(for)Tj
1.3889 0 Td
(sei-)Tj
-34.9282 -1.2983 Td
(zures)Tj
2.313 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.6576 0 Td
(proxy)Tj
2.5342 0 Td
(for)Tj
1.389 0 Td
(status)Tj
2.5001 0 Td
(epilepticus.)Tj
4.7168 0 Td
(The)Tj
1.7802 0 Td
(RAMPART)Tj
4.8925 0 Td
(trial)Tj
1.8369 0 Td
(began)Tj
2.6022 0 Td
(in)Tj
1.0318 0 Td
(June)Tj
2.0522 0 Td
(2009,)Tj
2.3471 0 Td
(concluded)Tj
4.3767 0 Td
(in)Tj
-36.0451 -1.2982 Td
(January)Tj
3.3165 0 Td
(2011,)Tj
2.3527 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4684 0 Td
(results)Tj
2.8062 0 Td
(were)Tj
2.126 0 Td
(published)Tj
4.1216 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(New)Tj
2.0636 0 Td
(England)Tj
3.5603 0 Td
(Journal)Tj
3.1861 0 Td
(of)Tj
1.0148 0 Td
(Medicine)Tj
3.9968 0 Td
(in)Tj
1.0318 0 Td
(Feb-)Tj
-35.2797 -1.3039 Td
(ruary)Tj
2.3754 0 Td
(2012.)Tj
2.3527 0 Td
(The)Tj
1.7802 0 Td
(University)Tj
4.405 0 Td
(of)Tj
1.0148 0 Td
(Michigan)Tj
4.0421 0 Td
(Institutional)Tj
5.1647 0 Td
(Review)Tj
3.0954 0 Td
(Board)Tj
2.6363 0 Td
(determined)Tj
4.8528 0 Td
(this)Tj
1.6725 0 Td
(project,)Tj
-33.3919 -1.2983 Td
(which)Tj
2.6475 0 Td
(used)Tj
2.0636 0 Td
(de-identified)Tj
5.3574 0 Td
(data,)Tj
2.1374 0 Td
(was)Tj
1.7007 0 Td
(not)Tj
1.5761 0 Td
(regulated)Tj
3.9345 0 Td
(human)Tj
3.0784 0 Td
(subjects)Tj
3.3788 0 Td
(research.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 190.9984 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Data)Tj
2.3102 0 Td
(source)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 173.9905 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(National)Tj
3.6907 0 Td
(Emergency)Tj
4.7225 0 Td
(Medical)Tj
3.4355 0 Td
(Services)Tj
3.4186 0 Td
(Information)Tj
5.1477 0 Td
(System)Tj
3.0557 0 Td
(\(NEMSIS\))Tj
4.388 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.652 0 Td
(national)Tj
3.5036 0 Td
(reposi-)Tj
-34.6448 -1.2982 Td
(tory)Tj
1.8481 0 Td
(of)Tj
1.0148 0 Td
(standardized)Tj
5.3575 0 Td
(patient)Tj
3.0047 0 Td
(care)Tj
1.8708 0 Td
(reports)Tj
3.0728 0 Td
(from)Tj
2.2053 0 Td
(EMS)Tj
2.16 0 Td
(activations)Tj
4.5127 0 Td
(from)Tj
2.2054 0 Td
(up)Tj
1.2642 0 Td
(to)Tj
1.0261 0 Td
(48)Tj
1.1679 0 Td
(U.S.)Tj
1.8822 0 Td
(States)Tj
2.5115 0 Td
(and)Tj
-35.104 -1.2983 Td
(territories)Tj
4.1782 0 Td
(depending)Tj
4.4674 0 Td
(on)Tj
1.2755 0 Td
(year.[)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(])Tj
3.2882 0 Td
(Data)Tj
2.1203 0 Td
(represent)Tj
3.9572 0 Td
(a)Tj
0.6576 0 Td
(convenience)Tj
5.21 0 Td
(sample)Tj
3.0218 0 Td
(collected)Tj
3.7417 0 Td
(by)Tj
1.1792 0 Td
(EMS)Tj
2.16 0 Td
(agen-)Tj
-35.2571 -1.3039 Td
(cies,)Tj
1.9218 0 Td
(submitted)Tj
4.2463 0 Td
(to)Tj
1.0261 0 Td
(state)Tj
2.0353 0 Td
(repositories,)Tj
5.1193 0 Td
(and)Tj
1.7292 0 Td
(consolidated)Tj
5.295 0 Td
(into)Tj
1.8426 0 Td
(the)Tj
1.4683 0 Td
(NEMSIS)Tj
3.7077 0 Td
(registry)Tj
3.2315 0 Td
(after)Tj
2.0352 0 Td
(a)Tj
0.6577 0 Td
(valida-)Tj
-34.316 -1.2983 Td
(tion)Tj
1.8425 0 Td
(and)Tj
1.7291 0 Td
(data)Tj
1.9105 0 Td
(cleaning)Tj
3.5773 0 Td
(process[)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(].)Tj
-7.8632 -1.2982 Td
(Using)Tj
2.6022 0 Td
(the)Tj
1.4683 0 Td
(NEMSIS)Tj
3.7077 0 Td
(dataset,)Tj
3.2258 0 Td
(we)Tj
1.3266 0 Td
(identified)Tj
4.0592 0 Td
(all)Tj
1.1452 0 Td
(patient)Tj
3.0047 0 Td
(care)Tj
1.8765 0 Td
(events)Tj
2.7269 0 Td
(involving)Tj
3.9798 0 Td
(adult)Tj
2.2564 0 Td
(and)Tj
1.7291 0 Td
(pediat-)Tj
-34.3046 -1.3039 Td
(ric)Tj
1.2812 0 Td
(patients)Tj
3.3675 0 Td
(who)Tj
1.9389 0 Td
(were)Tj
2.1203 0 Td
(treated)Tj
2.9991 0 Td
(with)Tj
1.9955 0 Td
(benzodiazepines)Tj
6.8031 0 Td
(for)Tj
1.389 0 Td
(seizures)Tj
3.3676 0 Td
(and)Tj
1.7291 0 Td
(presumed)Tj
4.1896 0 Td
(convulsive)Tj
4.4333 0 Td
(sta-)Tj
-35.6142 -1.2983 Td
(tus)Tj
1.4059 0 Td
(epilepticus)Tj
4.4901 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(pre-hospital)Tj
5.0456 0 Td
(setting,)Tj
3.1068 0 Td
(from)Tj
2.2053 0 Td
(January)Tj
3.3165 0 Td
(1,)Tj
0.9241 0 Td
(2010,)Tj
2.3471 0 Td
(through)Tj
3.4469 0 Td
(December)Tj
4.3483 0 Td
(31,)Tj
1.3947 0 Td
(2014.)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 385.1149 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(The)Tj
1.9204 0 Td
(effect)Tj
2.6292 0 Td
(of)Tj
1.0417 0 Td
(RAMPART)Tj
5.0528 0 Td
(on)Tj
1.3111 0 Td
(pre-hospital)Tj
5.3433 0 Td
(midazolam)Tj
4.9749 0 Td
(use)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01735)Tj
4.089 0 Td
(39)Tj
0 g
2.0906 0 Td
(March)Tj
2.9622 0 Td
(17,)Tj
1.5874 0 Td
(2017)Tj
34.3562 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(22)Tj
/F9 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(Loan)Tj
2.0622 0 Td
(Repayment)Tj
4.4504 0 Td
(program)Tj
3.4299 0 Td
(through)Tj
3.1465 0 Td
(the)Tj
1.3748 0 Td
(Nationa)Tj
2.8205 0 Td
(l)Tj
-17.2843 -1.3748 Td
(Institutes)Tj
3.6425 0 Td
(of)Tj
0.9496 0 Td
(Neurological)Tj
4.8544 0 Td
(Disorders)Tj
3.8268 0 Td
(and)Tj
1.5874 0 Td
(Stroke)Tj
-14.8607 -1.3749 Td
(\(L30)Tj
1.9488 0 Td
(NS089043\))Tj
4.2591 0 Td
(.)Tj
0.4464 0 Td
(Mr.)Tj
1.5024 0 Td
(Shtull-Lebe)Tj
4.2095 0 Td
(r)Tj
0.5315 0 Td
(received)Tj
-12.8977 -1.3748 Td
(support)Tj
3.0968 0 Td
(for)Tj
1.2544 0 Td
(this)Tj
1.5661 0 Td
(project)Tj
2.7638 0 Td
(through)Tj
3.1536 0 Td
(the)Tj
1.3677 0 Td
(Michigan)Tj
-13.2024 -1.3748 Td
(Institute)Tj
3.2244 0 Td
(For)Tj
1.4244 0 Td
(Clinical)Tj
2.8347 0 Td
(and)Tj
1.5874 0 Td
(Health)Tj
2.5724 0 Td
(Researc)Tj
2.9977 0 Td
(h,)Tj
0.9213 0 Td
(funded)Tj
-15.5623 -1.3748 Td
(by)Tj
1.1126 0 Td
(the)Tj
1.3748 0 Td
(Nationa)Tj
2.8205 0 Td
(l)Tj
0.4181 0 Td
(Center)Tj
2.622 0 Td
(for)Tj
1.2544 0 Td
(Advancing)Tj
4.0961 0 Td
(Translation)Tj
-13.6985 -1.3748 Td
(Science)Tj
3.0968 0 Td
(\(5TL1)Tj
2.4237 0 Td
(TR00043)Tj
3.4228 0 Td
(5\).)Tj
1.226 0 Td
(Dr.)Tj
1.3394 0 Td
(Meurer)Tj
2.9055 0 Td
(and)Tj
-14.4142 -1.3748 Td
(Silbergleit)Tj
3.8693 0 Td
(receive)Tj
2.8276 0 Td
(salary)Tj
2.4094 0 Td
(support)Tj
3.0969 0 Td
(from)Tj
2.0055 0 Td
(the)Tj
1.3748 0 Td
(Nationa)Tj
2.8205 0 Td
(l)Tj
-18.404 -1.3748 Td
(Institutes)Tj
3.6425 0 Td
(of)Tj
0.9496 0 Td
(Health)Tj
2.5725 0 Td
(for)Tj
1.2614 0 Td
(the)Tj
1.3677 0 Td
(Neurologi)Tj
3.593 0 Td
(cal)Tj
-13.3867 -1.3748 Td
(Emergencie)Tj
4.3583 0 Td
(s)Tj
0.6448 0 Td
(Treatment)Tj
4.004 0 Td
(Trials)Tj
2.2252 0 Td
(Network)Tj
3.3308 0 Td
(\(U01)Tj
-14.5631 -1.3749 Td
(NS056975\))Tj
4.259 0 Td
(.)Tj
0.4465 0 Td
(Dr.)Tj
1.3394 0 Td
(Meurer)Tj
2.9055 0 Td
(used)Tj
2.0055 0 Td
(departmenta)Tj
4.6772 0 Td
(l)Tj
-15.6331 -1.3748 Td
(discretiona)Tj
4.0535 0 Td
(ry)Tj
0.9496 0 Td
(research)Tj
3.4158 0 Td
(funds)Tj
2.3174 0 Td
(from)Tj
2.0126 0 Td
(the)Tj
1.3677 0 Td
(University)Tj
3.9118 0 Td
(of)Tj
-18.0284 -1.3748 Td
(Michigan)Tj
3.6212 0 Td
(Department)Tj
4.5922 0 Td
(of)Tj
0.9496 0 Td
(Emergenc)Tj
3.7418 0 Td
(y)Tj
0.6449 0 Td
(Medicine)Tj
3.5716 0 Td
(to)Tj
-17.1213 -1.3748 Td
(conduct)Tj
3.2102 0 Td
(this)Tj
1.5662 0 Td
(project.)Tj
2.9905 0 Td
(No)Tj
1.2756 0 Td
(funding)Tj
3.0402 0 Td
(bodies)Tj
2.6717 0 Td
(had)Tj
1.5945 0 Td
(any)Tj
-16.3489 -1.3748 Td
(role)Tj
1.6157 0 Td
(in)Tj
0.8858 0 Td
(study)Tj
2.2678 0 Td
(design,)Tj
2.8984 0 Td
(data)Tj
1.793 0 Td
(collection)Tj
3.7346 0 Td
(and)Tj
1.5874 0 Td
(analysis,)Tj
-14.7827 -1.3748 Td
(decision)Tj
3.2882 0 Td
(to)Tj
0.9496 0 Td
(publish,)Tj
3.1465 0 Td
(or)Tj
0.9992 0 Td
(preparation)Tj
4.4433 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
-13.7764 -1.3748 Td
(manuscript.)Tj
/F8 1 Tf
0 -2.126 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F9 1 Tf
0.4819 0 Td
(The)Tj
1.5875 0 Td
(authors)Tj
3.0401 0 Td
(have)Tj
1.963 0 Td
(declared)Tj
-14.7827 -1.3749 Td
(that)Tj
1.6228 0 Td
(no)Tj
1.1693 0 Td
(competing)Tj
4.1599 0 Td
(interests)Tj
3.3874 0 Td
(exist.)Tj
/F8 1 Tf
-10.3394 -2.126 Td
(Abbreviati)Tj
3.9118 0 Td
(ons:)Tj
/F9 1 Tf
1.8425 0 Td
(95%)Tj
1.9772 0 Td
(CI)Tj
0.9992 0 Td
(denotes,)Tj
3.3875 0 Td
(95%)Tj
1.97 0 Td
(confidence)Tj
-14.0882 -1.3748 Td
(interval;)Tj
3.1323 0 Td
(ALS,)Tj
1.9701 0 Td
(advanced)Tj
3.7417 0 Td
(life)Tj
1.2827 0 Td
(support;)Tj
3.3236 0 Td
(BLS,)Tj
1.9701 0 Td
(basic)Tj
2.1473 0 Td
(life)Tj
-17.5678 -1.3748 Td
(support;)Tj
3.3236 0 Td
(EMS,)Tj
2.1969 0 Td
(emergen)Tj
3.2669 0 Td
(cy)Tj
1.063 0 Td
(medical)Tj
3.104 0 Td
(services;)Tj
3.4725 0 Td
(ICC,)Tj
-16.4269 -1.3748 Td
(intra-class)Tj
4.0535 0 Td
(correlation;)Tj
4.3867 0 Td
(IV,)Tj
1.226 0 Td
(intra-venous)Tj
4.6417 0 Td
(;)Tj
0.4465 0 Td
(NEMSIS,)Tj
-14.7544 -1.3748 Td
(National)Tj
3.2386 0 Td
(EMS)Tj
1.9701 0 Td
(Information)Tj
4.5567 0 Td
(System;)Tj
3.2457 0 Td
(OR,)Tj
1.6157 0 Td
(odds)Tj
-14.6268 -1.3748 Td
(ration;)Tj
2.5653 0 Td
(RAMPART,)Tj
4.4221 0 Td
(Rapid)Tj
2.374 0 Td
(Anticonvu)Tj
3.7064 0 Td
(lsant)Tj
-13.0678 -1.3748 Td
(Medication)Tj
4.3016 0 Td
(Prior)Tj
2.0267 0 Td
(to)Tj
ET
endstream
endobj
22 0 obj
<>stream
endstream
endobj
23 0 obj
<>stream
endstream
endobj
24 0 obj
<>stream
endstream
endobj
25 0 obj
<>stream
endstream
endobj
26 0 obj
<>stream
endstream
endobj
27 0 obj
<>stream
endstream
endobj
28 0 obj
<>stream
endstream
endobj
29 0 obj
<>stream
BT
7.278 48.2177 Td
(Arrival.)Tj
ET
Q
endstream
endobj
30 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 11 0 R/Annots 31 0 R/Contents 32 0 R/TrimBox[0 0 612 792]>>
endobj
31 0 obj
[33 0 R]
endobj
33 0 obj
<>/Border[0 0 0]/A 34 0 R>>
endobj
34 0 obj
<>
endobj
32 0 obj
[35 0 R 36 0 R]
endobj
35 0 obj
<>stream
q
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Since)Tj
2.3584 0 Td
(the)Tj
1.4683 0 Td
(NEMSIS)Tj
3.7077 0 Td
(database)Tj
3.6397 0 Td
(does)Tj
2.0409 0 Td
(not)Tj
1.576 0 Td
(include)Tj
3.1805 0 Td
(a)Tj
0.6576 0 Td
(diagnostic)Tj
4.3143 0 Td
(code)Tj
2.1033 0 Td
(to)Tj
1.0262 0 Td
(differentiate)Tj
5.0796 0 Td
(status)Tj
2.5002 0 Td
(epilepti-)Tj
-33.6527 -1.3039 Td
(cus)Tj
1.5306 0 Td
(from)Tj
2.2054 0 Td
(other)Tj
2.3471 0 Td
(seizures,)Tj
3.5943 0 Td
(and)Tj
1.7291 0 Td
(duration)Tj
3.702 0 Td
(between)Tj
3.532 0 Td
(911)Tj
1.644 0 Td
(call)Tj
1.5704 0 Td
(and)Tj
1.7292 0 Td
(EMS)Tj
2.1599 0 Td
(arrival)Tj
2.8007 0 Td
(is)Tj
0.8447 0 Td
(almost)Tj
2.8856 0 Td
(universally)Tj
-32.275 -1.2982 Td
(greater)Tj
3.0047 0 Td
(than)Tj
2.0295 0 Td
(five)Tj
1.6555 0 Td
(minutes)Tj
3.4639 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(United)Tj
3.0217 0 Td
(States,)Tj
2.7383 0 Td
(presumed)Tj
4.1895 0 Td
(status)Tj
2.5002 0 Td
(epilepticus)Tj
4.49 0 Td
(was)Tj
1.7008 0 Td
(operationalized)Tj
-31.2999 -1.2983 Td
(as)Tj
1.0147 0 Td
(the)Tj
1.4684 0 Td
(presence)Tj
3.7133 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(seizure)Tj
3.0104 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4683 0 Td
(administration)Tj
6.1682 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.6576 0 Td
(benzodiazepine.)Tj
6.6614 0 Td
(In)Tj
1.1112 0 Td
(an)Tj
1.2019 0 Td
(attempt)Tj
3.3108 0 Td
(to)Tj
1.0261 0 Td
(mini-)Tj
-35.223 -1.2983 Td
(mize)Tj
2.1373 0 Td
(the)Tj
1.4626 0 Td
(over-inclusion)Tj
6.0151 0 Td
(of)Tj
1.0091 0 Td
(benzodiazepine-treated)Tj
9.5641 0 Td
(seizures)Tj
3.3618 0 Td
(that)Tj
1.7688 0 Td
(would)Tj
2.7099 0 Td
(not)Tj
1.5648 0 Td
(qualify)Tj
2.9423 0 Td
(as)Tj
1.0091 0 Td
(status)Tj
2.4888 0 Td
(epi-)Tj
-36.0337 -1.3039 Td
(lepticus)Tj
3.2824 0 Td
(we)Tj
1.3267 0 Td
(utilized)Tj
3.1917 0 Td
(two)Tj
1.7122 0 Td
(sampling)Tj
3.8777 0 Td
(strategies)Tj
3.9232 0 Td
(for)Tj
1.3833 0 Td
(benzodiazepine-treat)Tj
8.4018 0 Td
(ed)Tj
1.1679 0 Td
(seizures)Tj
3.3675 0 Td
(and)Tj
1.7291 0 Td
(based)Tj
2.4775 0 Td
(the)Tj
-35.841 -1.2982 Td
(analysis)Tj
3.3278 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(narrower)Tj
3.9288 0 Td
(strategy.)Tj
3.5546 0 Td
(First,)Tj
2.2677 0 Td
(using)Tj
2.3925 0 Td
(the)Tj
1.4683 0 Td
(following)Tj
3.9798 0 Td
(Field)Tj
2.211 0 Td
(Codes,)Tj
2.9254 0 Td
(events)Tj
2.7325 0 Td
(were)Tj
2.1204 0 Td
(sampled)Tj
-33.6527 -1.2983 Td
(where)Tj
2.6475 0 Td
(seizure)Tj
3.0104 0 Td
(was)Tj
1.6951 0 Td
(coded)Tj
2.6305 0 Td
(in)Tj
1.0375 0 Td
(either)Tj
2.5285 0 Td
(the)Tj
1.474 0 Td
(chief)Tj
2.1486 0 Td
(complaint)Tj
4.2803 0 Td
(as)Tj
1.0148 0 Td
(reported)Tj
3.6623 0 Td
(by)Tj
1.1793 0 Td
(dispatch)Tj
3.5773 0 Td
(\(455\),)Tj
2.5511 0 Td
(the)Tj
1.4684 0 Td
(CMS)Tj
-34.9056 -1.3039 Td
(condition)Tj
4.1158 0 Td
(code)Tj
2.0977 0 Td
(\(8017\),)Tj
3.0273 0 Td
(or)Tj
1.0999 0 Td
(the)Tj
1.4683 0 Td
(EMS)Tj
2.16 0 Td
(provider's)Tj
4.2349 0 Td
(primary)Tj
3.4583 0 Td
(\(1710\))Tj
2.8006 0 Td
(or)Tj
1.0998 0 Td
(secondary)Tj
4.269 0 Td
(impression)Tj
4.6658 0 Td
(\(1845\).)Tj
-34.4974 -1.2983 Td
(Second,)Tj
3.3505 0 Td
(sampling)Tj
3.8778 0 Td
(was)Tj
1.7007 0 Td
(narrowed)Tj
4.0876 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(primary)Tj
3.4526 0 Td
(or)Tj
1.0998 0 Td
(secondary)Tj
4.2747 0 Td
(impression.)Tj
4.8869 0 Td
(After)Tj
2.2847 0 Td
(limiting)Tj
3.4015 0 Td
(the)Tj
-34.9112 -1.2983 Td
(samples)Tj
3.3788 0 Td
(to)Tj
1.0262 0 Td
(those)Tj
2.3414 0 Td
(treated)Tj
2.9933 0 Td
(with)Tj
1.9956 0 Td
(benzodiazepines,)Tj
7.0299 0 Td
(the)Tj
1.4683 0 Td
(total)Tj
2.0069 0 Td
(eligible)Tj
3.0614 0 Td
(population)Tj
4.5921 0 Td
(was)Tj
1.7008 0 Td
(similar)Tj
2.9877 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
-35.9657 -1.3039 Td
(two)Tj
1.7064 0 Td
(seizure)Tj
3.0104 0 Td
(sampling)Tj
3.8777 0 Td
(strategies,)Tj
4.1499 0 Td
(so)Tj
1.0885 0 Td
(the)Tj
1.4684 0 Td
(latter,)Tj
2.5171 0 Td
(narrow)Tj
3.1351 0 Td
(strategy)Tj
3.3279 0 Td
(was)Tj
1.6951 0 Td
(chosen)Tj
3.016 0 Td
(for)Tj
1.3833 0 Td
(a)Tj
0.652 0 Td
(more)Tj
2.3414 0 Td
(precise)Tj
-33.3692 -1.2982 Td
(operational)Tj
4.7735 0 Td
(definition)Tj
4.1612 0 Td
(of)Tj
1.0148 0 Td
(presumed)Tj
4.1952 0 Td
(status)Tj
2.5002 0 Td
(epilepticus.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 516.0188 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Measures)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 499.011 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(primary)Tj
3.4582 0 Td
(outcome)Tj
3.7247 0 Td
(measure)Tj
3.583 0 Td
(is)Tj
0.8447 0 Td
(midazolam)Tj
4.6885 0 Td
(use)Tj
1.5307 0 Td
(as)Tj
1.0148 0 Td
(first-line)Tj
3.6453 0 Td
(treatment,)Tj
4.3597 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(proportion)Tj
4.6317 0 Td
(of)Tj
1.0148 0 Td
(all)Tj
-35.943 -1.3039 Td
(benzodiazepine-treated)Tj
9.564 0 Td
(seizures,)Tj
3.5943 0 Td
(evaluated)Tj
3.9911 0 Td
(monthly.)Tj
3.8495 0 Td
(First-line)Tj
3.8777 0 Td
(medication)Tj
4.7395 0 Td
(was)Tj
1.7008 0 Td
(defined)Tj
3.2258 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
-35.5575 -1.2982 Td
(first)Tj
1.7971 0 Td
(medication)Tj
4.7282 0 Td
(listed)Tj
2.33 0 Td
(in)Tj
1.0262 0 Td
(the)Tj
1.4626 0 Td
(medications)Tj
5.4822 0 Td
(given)Tj
2.7609 0 Td
(variable)Tj
3.3506 0 Td
(for)Tj
1.3776 0 Td
(a)Tj
0.6406 0 Td
(patient)Tj
2.999 0 Td
(care)Tj
1.8652 0 Td
(event.)Tj
2.5852 0 Td
(While)Tj
2.6419 0 Td
(RAM-)Tj
-35.0473 -1.2983 Td
(PART)Tj
2.6928 0 Td
(demonstrated)Tj
5.76 0 Td
(the)Tj
1.474 0 Td
(efficacy)Tj
3.2202 0 Td
(specifically)Tj
4.5694 0 Td
(of)Tj
1.0148 0 Td
(intramuscular)Tj
5.8506 0 Td
(midazolam,)Tj
4.9153 0 Td
(medication)Tj
4.7395 0 Td
(route)Tj
2.3471 0 Td
(is)Tj
-36.5837 -1.2983 Td
(not)Tj
1.5703 0 Td
(available)Tj
3.668 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4684 0 Td
(NEMSIS)Tj
3.7076 0 Td
(database.)Tj
3.8665 0 Td
(Venous)Tj
3.2825 0 Td
(access)Tj
2.6475 0 Td
(procedures)Tj
4.6715 0 Td
(could)Tj
2.4548 0 Td
(not)Tj
1.5704 0 Td
(be)Tj
1.1508 0 Td
(used)Tj
2.0636 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(proxy)Tj
-34.8262 -1.3039 Td
(for)Tj
1.3832 0 Td
(intravenous)Tj
4.9606 0 Td
(\(IV\))Tj
1.9389 0 Td
(administration)Tj
6.1682 0 Td
(of)Tj
1.0148 0 Td
(medications,)Tj
5.3234 0 Td
(as)Tj
1.0148 0 Td
(they)Tj
1.9219 0 Td
(were)Tj
2.126 0 Td
(equally)Tj
3.0557 0 Td
(as)Tj
1.0148 0 Td
(common)Tj
3.8494 0 Td
(for)Tj
1.3833 0 Td
(those)Tj
-35.155 -1.2982 Td
(treated)Tj
2.9933 0 Td
(with)Tj
2.0013 0 Td
(midazolam)Tj
4.6884 0 Td
(as)Tj
1.0148 0 Td
(for)Tj
1.3833 0 Td
(those)Tj
2.3358 0 Td
(treated)Tj
2.999 0 Td
(with)Tj
1.9956 0 Td
(other,)Tj
2.5738 0 Td
(IV-administrable,)Tj
7.336 0 Td
(benzodiazepines)Tj
-29.3213 -1.2983 Td
(\(67.0%)Tj
2.9706 0 Td
(and)Tj
1.7292 0 Td
(68.8%,)Tj
2.8516 0 Td
(respectively\).)Tj
-6.3552 -1.3039 Td
(The)Tj
1.7858 0 Td
(main)Tj
2.2904 0 Td
(predictor)Tj
3.9231 0 Td
(is)Tj
0.8504 0 Td
(an)Tj
1.2019 0 Td
(indicator)Tj
3.8664 0 Td
(variable)Tj
3.3562 0 Td
(for)Tj
1.3833 0 Td
(events)Tj
2.7326 0 Td
(occurring)Tj
4.1272 0 Td
(after)Tj
2.0352 0 Td
(RAMPART)Tj
4.8926 0 Td
(publica-)Tj
-33.6413 -1.2983 Td
(tion)Tj
1.8425 0 Td
(in)Tj
1.0318 0 Td
(February)Tj
3.838 0 Td
(2012.)Tj
2.3471 0 Td
(Age,)Tj
2.0183 0 Td
(reported)Tj
3.6623 0 Td
(in)Tj
1.0318 0 Td
(units)Tj
2.228 0 Td
(of)Tj
1.0148 0 Td
(hours,)Tj
2.7383 0 Td
(days,)Tj
2.2223 0 Td
(months,)Tj
3.5093 0 Td
(and)Tj
1.7291 0 Td
(years,)Tj
2.4888 0 Td
(was)Tj
1.7008 0 Td
(converted)Tj
-33.4032 -1.2983 Td
(to)Tj
1.0261 0 Td
(years)Tj
2.262 0 Td
(and)Tj
1.7291 0 Td
(analyzed)Tj
3.7021 0 Td
(continuously)Tj
5.4368 0 Td
(and)Tj
1.7348 0 Td
(categorically)Tj
5.21 0 Td
(according)Tj
4.1896 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(age)Tj
1.542 0 Td
(categories)Tj
4.1953 0 Td
(used)Tj
2.0579 0 Td
(in)Tj
-35.5802 -1.3039 Td
(RAMPART.)Tj
5.1193 0 Td
(Gender)Tj
3.2315 0 Td
(was)Tj
1.6951 0 Td
(evenly)Tj
2.7722 0 Td
(distributed)Tj
4.5978 0 Td
(at)Tj
0.9524 0 Td
(baseline)Tj
3.4299 0 Td
(\(50.8%)Tj
2.9707 0 Td
(male,)Tj
2.3698 0 Td
(49.2%)Tj
2.6248 0 Td
(female\).)Tj
-28.5673 -1.2982 Td
(Patient)Tj
3.05 0 Td
(race)Tj
1.8709 0 Td
(\(black,)Tj
2.897 0 Td
(white,)Tj
2.6418 0 Td
(other\))Tj
2.6929 0 Td
(and)Tj
1.7292 0 Td
(ethnicity)Tj
3.7303 0 Td
(\(Hispanic,)Tj
4.371 0 Td
(not)Tj
1.5704 0 Td
(Hispanic\))Tj
4.1499 0 Td
(were)Tj
2.1203 0 Td
(included)Tj
3.7134 0 Td
(to)Tj
-35.7333 -1.2983 Td
(look)Tj
1.9729 0 Td
(for)Tj
1.3889 0 Td
(disparities)Tj
4.3143 0 Td
(in)Tj
1.0375 0 Td
(rates)Tj
2.109 0 Td
(of)Tj
1.0148 0 Td
(knowledge)Tj
4.541 0 Td
(translation.)Tj
4.7565 0 Td
(Geographic)Tj
4.8756 0 Td
(distribution)Tj
4.9663 0 Td
(of)Tj
1.0148 0 Td
(events)Tj
2.7325 0 Td
(was)Tj
-34.7241 -1.2983 Td
(defined)Tj
3.2258 0 Td
(by)Tj
1.1792 0 Td
(US)Tj
1.4343 0 Td
(Census)Tj
3.1067 0 Td
(Regions)Tj
3.4129 0 Td
(\(Northeast,)Tj
4.7395 0 Td
(Midwest,)Tj
3.9005 0 Td
(South,)Tj
2.7836 0 Td
(West\),)Tj
2.8346 0 Td
(and)Tj
1.7291 0 Td
(levels)Tj
2.3754 0 Td
(of)Tj
1.0148 0 Td
(urbanicity)Tj
-31.7364 -1.3039 Td
(\(urban,)Tj
3.1747 0 Td
(suburban,)Tj
4.2293 0 Td
(rural,)Tj
2.3924 0 Td
(wilderness\).)Tj
5.0003 0 Td
(Characteristics)Tj
6.1455 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(EMS)Tj
2.16 0 Td
(encounter,)Tj
4.5184 0 Td
(including)Tj
4.0422 0 Td
(service)Tj
-34.1459 -1.2982 Td
(level)Tj
2.0125 0 Td
(\(basic)Tj
2.5512 0 Td
(life)Tj
1.4457 0 Td
(support)Tj
3.3221 0 Td
(\(BLS\),)Tj
2.7156 0 Td
(advanced)Tj
3.9968 0 Td
(life)Tj
1.4457 0 Td
(support)Tj
3.3165 0 Td
(\(ALS\),)Tj
2.8233 0 Td
(air,)Tj
1.5194 0 Td
(other\),)Tj
2.914 0 Td
(primary)Tj
3.4525 0 Td
(role)Tj
1.7688 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(unit)Tj
-35.7673 -1.2983 Td
(\(transport,)Tj
4.49 0 Td
(other\),)Tj
2.914 0 Td
(and)Tj
1.7291 0 Td
(type)Tj
1.9162 0 Td
(of)Tj
1.0148 0 Td
(service)Tj
2.9424 0 Td
(requested)Tj
4.0875 0 Td
(\(911)Tj
1.9842 0 Td
(response,)Tj
3.9572 0 Td
(inter-facility)Tj
5.159 0 Td
(transfer,)Tj
3.5433 0 Td
(other\))Tj
-33.7377 -1.3039 Td
(were)Tj
2.1203 0 Td
(included)Tj
3.7133 0 Td
(given)Tj
2.3811 0 Td
(our)Tj
1.6214 0 Td
(a)Tj
0.6576 0 Td
(priori)Tj
2.5172 0 Td
(belief)Tj
2.3754 0 Td
(of)Tj
1.0148 0 Td
(an)Tj
1.2076 0 Td
(association)Tj
4.6261 0 Td
(with)Tj
1.9955 0 Td
(midazolam)Tj
4.6885 0 Td
(use.)Tj
1.7575 0 Td
(Average)Tj
3.4752 0 Td
(annual)Tj
-34.1515 -1.2983 Td
(call)Tj
1.5703 0 Td
(volume)Tj
3.1975 0 Td
(for)Tj
1.3833 0 Td
(represented)Tj
4.9096 0 Td
(years)Tj
2.2677 0 Td
(was)Tj
1.7007 0 Td
(calculated)Tj
4.201 0 Td
(and)Tj
1.7291 0 Td
(used)Tj
2.0636 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(proxy)Tj
2.5341 0 Td
(for)Tj
1.389 0 Td
(EMS)Tj
2.16 0 Td
(agency)Tj
2.965 0 Td
(size.)Tj
-32.5415 -1.2983 Td
(Secondary)Tj
4.388 0 Td
(outcome)Tj
3.7247 0 Td
(measures)Tj
3.9458 0 Td
(include)Tj
3.1804 0 Td
(airway)Tj
2.8687 0 Td
(intervention)Tj
5.176 0 Td
(and)Tj
1.7291 0 Td
(rescue)Tj
2.7496 0 Td
(therapy,)Tj
3.4753 0 Td
(as)Tj
1.0148 0 Td
(proxies)Tj
-33.4486 -1.3039 Td
(for)Tj
1.3832 0 Td
(safety)Tj
2.4832 0 Td
(and)Tj
1.7291 0 Td
(efficacy)Tj
3.2201 0 Td
(of)Tj
1.0148 0 Td
(seizure)Tj
3.0104 0 Td
(termination,)Tj
5.2271 0 Td
(respectively.)Tj
5.108 0 Td
(Airway)Tj
3.1181 0 Td
(intervention)Tj
5.176 0 Td
(was)Tj
1.7008 0 Td
(defined)Tj
3.2258 0 Td
(as)Tj
-36.3966 -1.2982 Td
(any)Tj
1.6554 0 Td
(invasive)Tj
3.4299 0 Td
(procedure)Tj
4.3143 0 Td
(to)Tj
1.0261 0 Td
(secure)Tj
2.7496 0 Td
(the)Tj
1.4683 0 Td
(tracheal)Tj
3.3789 0 Td
(airway,)Tj
3.0898 0 Td
(including)Tj
4.0421 0 Td
(any)Tj
1.6611 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(following)Tj
3.9798 0 Td
(procedure)Tj
-33.2785 -1.2983 Td
(codes:)Tj
2.6872 0 Td
(31.420)Tj
2.8233 0 Td
(\(direct)Tj
2.8686 0 Td
(laryngoscopy\),)Tj
6.0775 0 Td
(96.042)Tj
2.8232 0 Td
(\(rapid)Tj
2.6759 0 Td
(sequence)Tj
3.8608 0 Td
(intubation\),)Tj
4.9889 0 Td
(96.051)Tj
2.8233 0 Td
(\(combitube)Tj
-31.6287 -1.3039 Td
(blind)Tj
2.313 0 Td
(insertion)Tj
3.8154 0 Td
(airway)Tj
2.863 0 Td
(device\),)Tj
3.3052 0 Td
(96.030)Tj
2.8233 0 Td
(\(esophageal)Tj
4.9039 0 Td
(obturator)Tj
4.0365 0 Td
(airway/esophageal)Tj
7.5344 0 Td
(gastric)Tj
2.8403 0 Td
(tube)Tj
-34.435 -1.2983 Td
(airway\),)Tj
3.4242 0 Td
(96.053)Tj
2.8119 0 Td
(\(King)Tj
2.5115 0 Td
(LT)Tj
1.3606 0 Td
(blind)Tj
2.3074 0 Td
(insertion)Tj
3.8041 0 Td
(airway)Tj
2.8573 0 Td
(device\),)Tj
3.2995 0 Td
(96.052)Tj
2.8176 0 Td
(\(laryngeal)Tj
4.1783 0 Td
(mask)Tj
2.3187 0 Td
(blind)Tj
2.313 0 Td
(insertion)Tj
-34.0041 -1.2983 Td
(airway)Tj
2.8629 0 Td
(device\),)Tj
3.3052 0 Td
(96.041)Tj
2.8233 0 Td
(\(nasotracheal)Tj
5.5729 0 Td
(intubation\),)Tj
4.9889 0 Td
(96.040)Tj
2.8233 0 Td
(\(orotracheal)Tj
5.1023 0 Td
(intubation\),)Tj
4.989 0 Td
(and)Tj
1.7291 0 Td
(31.120)Tj
-34.1969 -1.2982 Td
(\(surgical)Tj
3.6566 0 Td
(cricothyrotomy\).)Tj
7.0129 0 Td
(Rescue)Tj
3.0047 0 Td
(therapy,)Tj
3.4696 0 Td
(or)Tj
1.0998 0 Td
(the)Tj
1.4684 0 Td
(administration)Tj
6.1681 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.6576 0 Td
(second)Tj
3.0104 0 Td
(drug)Tj
2.109 0 Td
(or)Tj
1.0998 0 Td
(dose)Tj
2.0409 0 Td
(to)Tj
-35.8126 -1.3039 Td
(terminate)Tj
4.1045 0 Td
(a)Tj
0.652 0 Td
(seizure,)Tj
3.2314 0 Td
(was)Tj
1.7008 0 Td
(defined)Tj
3.2258 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.474 0 Td
(presence)Tj
3.7077 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.6576 0 Td
(second)Tj
3.0104 0 Td
(benzodiazepine)Tj
6.4403 0 Td
(listed)Tj
2.3414 0 Td
(under)Tj
-32.7399 -1.2983 Td
(medications)Tj
5.4878 0 Td
(given.)Tj
-4.2916 -1.2983 Td
(Explanatory)Tj
5.0683 0 Td
(variables)Tj
3.719 0 Td
(for)Tj
1.3833 0 Td
(secondary)Tj
4.2746 0 Td
(analysis)Tj
3.3279 0 Td
(are)Tj
1.4456 0 Td
(identical)Tj
3.6567 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(primary)Tj
3.4582 0 Td
(analysis)Tj
3.3222 0 Td
(with)Tj
2.0013 0 Td
(the)Tj
-35.3478 -1.3039 Td
(addition)Tj
3.5943 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.6576 0 Td
(binary)Tj
2.8006 0 Td
(variable)Tj
3.3562 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(use)Tj
1.5307 0 Td
(of)Tj
1.0148 0 Td
(midazolam)Tj
4.6885 0 Td
(versus)Tj
2.7212 0 Td
(other)Tj
2.3471 0 Td
(benzodiazepines,)Tj
7.0299 0 Td
(and)Tj
1.7291 0 Td
(its)Tj
-35.3421 -1.2982 Td
(interaction)Tj
4.6034 0 Td
(with)Tj
2.0012 0 Td
(time.)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 385.1149 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(The)Tj
1.9204 0 Td
(effect)Tj
2.6292 0 Td
(of)Tj
1.0417 0 Td
(RAMPART)Tj
5.0528 0 Td
(on)Tj
1.3111 0 Td
(pre-hospital)Tj
5.3433 0 Td
(midazolam)Tj
4.9749 0 Td
(use)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01735)Tj
4.089 0 Td
(39)Tj
0 g
2.0906 0 Td
(March)Tj
2.9622 0 Td
(17,)Tj
1.5874 0 Td
(2017)Tj
34.3562 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
36 0 obj
<>stream
BT
66.402 0 Td
(22)Tj
ET
Q
endstream
endobj
37 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 11 0 R/Annots 43 0 R/Contents 44 0 R/TrimBox[0 0 612 792]>>
endobj
38 0 obj
<>
endobj
45 0 obj
<>
endobj
48 0 obj
<>stream
MinionPro-It 9 `ab]+
W W X? ' - 3 > H N T Z ` j q t { +2=CIU[cnz~
"(.9CIOU[elov|&-8>DPV^iuy &+/49@DGLPU[]_ahjmru|
&-4;BIPW^elsz
")07>ELSZahov} %,3:AHOV]dkry#/;JTey ! ( / 6 = D K R Y ` g n u |
$
+
2
9
@
G
N
U
\
c
j
q
x
'.5<CJQX_fmt{ #*18?FMT[bkry
"
)
0
7
>
E
J
O
W
d
q
v
$+29@GNU\cjqx '.5<CJQX_fmt{ #*18?FMT[bipw~
&-4;BIPW^elsz !(/6=DOVcpuz-B\v$<Tdy*5@Tanz!2>O_fmt{ #*18?FMT[bipw~(4@LZk{ "3EU_px!-?IUas $6BN\m
-:EQ]n}
%.7@IR[dmv!*3<ENW`ir{&/8AJS\enw ! * 3 < E N W ` i r { !!
!""commaaccentAbreveAmacronAogonekAEacuteCacuteCcaronCcircumflexCdotaccentDcaronDcroatEbreveEcaronEdotaccentEmacronEngEogonekGbreveGcircumflexGcommaaccentGdotaccentHbarHcircumflexIbreveIJImacronIogonekItildeJcircumflexKcommaaccentLacuteLcaronLcommaaccentLdotNacuteNcaronNcommaaccentObreveOhungarumlautOmacronOslashacuteRacuteRcaronRcommaaccentSacuteScedillaScircumflexScommaaccentTbarTcaronTcommaaccentUbreveUhungarumlautUmacronUogonekUringUtildeWacuteWcircumflexWdieresisWgraveYcircumflexYgraveZacuteZdotaccentIdotaccentabreveamacronaogonekaeacutecacuteccaronccircumflexcdotaccentdcarondcroatebreveecaronedotaccentemacronengeogonekgbrevegcircumflexgcommaaccentgdotaccenthbarhcircumflexibreveijimacroniogonekitildejcircumflexkcommaaccentlacutelcaronlcommaaccentldotnacutencaronncommaaccentobreveohungarumlautomacronoslashacuteracutercaronrcommaaccentsacutescedillascircumflexscommaaccenttbartcarontcommaaccentubreveuhungarumlautumacronuogonekuringutildewacutewcircumflexwdieresiswgraveycircumflexygravezacutezdotaccentkgreenlandiclongsnapostrophetonosdieresistonosAlphaBetaGammaDeltaEpsilonZetaEtaThetaIotaKappaLambdaMuNuXiOmicronPiRhoSigmaTauUpsilonPhiChiPsiOmegaAlphatonosEpsilontonosEtatonosIotatonosIotadieresisOmicrontonosUpsilontonosUpsilondieresisOmegatonosuni1FBBuni1F09uni1F0Duni1F0Buni1F0Funi1FB8uni1FBAuni1FBCuni1F89uni1F8Duni1F8Buni1F8Funi1F88uni1F8Cuni1F8Auni1F8Euni1F08uni1F0Cuni1F0Auni1F0Euni1FB9uni1FC9uni1F19uni1F1Duni1F1Buni1FC8uni1F18uni1F1Cuni1F1Auni1FCBuni1F29uni1F2Duni1F2Buni1F2Funi1FCAuni1FCCuni1F99uni1F9Duni1F9Buni1F9Funi1F98uni1F9Cuni1F9Auni1F9Euni1F28uni1F2Cuni1F2Auni1F2Euni1FDBuni1F39uni1F3Duni1F3Buni1F3Funi1FD8uni1FDAuni1F38uni1F3Cuni1F3Auni1F3Euni1FD9uni1FFBuni1F69uni1F6Duni1F6Buni1F6Funi1FFAuni1FFCuni1FA9uni1FADuni1FABuni1FAFuni1FA8uni1FACuni1FAAuni1FAEuni1F68uni1F6Cuni1F6Auni1F6Euni1FF9uni1F49uni1F4Duni1F4Buni1FF8uni1F48uni1F4Cuni1F4Auni1FECuni1FEBuni1F59uni1F5Duni1F5Buni1F5Funi1FE8uni1FEAuni1FE9alphabetagammadeltaepsilonzetaetathetaiotakappalambdanuxiomicronpirhosigmatauupsilonphichipsiomegaalphatonosepsilontonosetatonosiotatonosiotadieresisomicrontonosupsilontonosupsilondieresisomegatonosiotadieresistonosupsilondieresistonosuni03C2uni0374uni0375uni037Euni03D0uni03DAuni03DEuni03E0uni03F0uni1FBDuni1FBEuni1FC1uni1FCDuni1FCEuni1FCFuni1FDDuni1FDEuni1FDFuni1FEDuni1FEEuni1FFEuni1F00uni1F01uni1F02uni1F03uni1F04uni1F05uni1F06uni1F07uni1F10uni1F11uni1F12uni1F13uni1F14uni1F15uni1F20uni1F21uni1F22uni1F23uni1F24uni1F25uni1F26uni1F27uni1F30uni1F31uni1F32uni1F33uni1F34uni1F35uni1F36uni1F37uni1F40uni1F41uni1F42uni1F43uni1F44uni1F45uni1F50uni1F51uni1F52uni1F53uni1F54uni1F55uni1F56uni1F57uni1F60uni1F61uni1F62uni1F63uni1F64uni1F65uni1F66uni1F67uni1F70uni1F71uni1F72uni1F73uni1F74uni1F75uni1F76uni1F77uni1F78uni1F79uni1F7Auni1F7Buni1F7Cuni1F7Duni1F80uni1F81uni1F82uni1F83uni1F84uni1F85uni1F86uni1F87uni1F90uni1F91uni1F92uni1F93uni1F94uni1F95uni1F96uni1F97uni1FA0uni1FA1uni1FA2uni1FA3uni1FA4uni1FA5uni1FA6uni1FA7uni1FB0uni1FB1uni1FB2uni1FB3uni1FB6uni1FB7uni1FC2uni1FC3uni1FC4uni1FC6uni1FC7uni1FD0uni1FD1uni1FD2uni1FD3uni1FD6uni1FD7uni1FE0uni1FE1uni1FE2uni1FE3uni1FE4uni1FE5uni1FE6uni1FF2uni1FF3uni1FF4uni1FF6uni1FF7uni1FB4uni1FE7uniEFD5anoteleiauni03D1uni03D5uni03D6franclirapesetaEuroafii61289estimatedpartialdiffproductsummationuni2219radicalinfinityintegralapproxequalnotequallessequalgreaterequallozengeuni02C9uniEFEDuniEFEEuniEFF1uniEFF2uniEFF3uniEFF5uniEFF7AcuteCaronDieresisDieresisAcuteDieresisGraveGraveHungarumlautMacroncyrBrevecyrFlexdblGravecyrbrevecyrflexdblgravedieresisacutedieresisgraveuniF635uniF637uniF638uniF639uniF6DCuniF63AuniF63BuniF63CuniF63DuniF63EuniF63FuniF640uniF641uniF642uniF628uniF643uniF644uniF645uniF646uniF647uniF648uniF649uniF64AuniF64BuniF64CuniF64DuniF64EuniF64FuniF650uniF651uniF652uniF653uniF654uniF655uniF656uniF657uniF658uniF659uniF65AuniF65BuniF65CuniF65DuniF65EuniF65FuniF660uniF629uniF62AuniF62BuniF62CuniF62DuniF661uniF662uniF663uniF664uniF665uniF666uniF667uniF668uniF669uniF66AuniF66BuniF66CuniF62EuniF62FuniF630uniF631uniF632uniF66DuniF66EuniF66FuniF670uniF671uniF672uniF673uniF674uniF675uniF676uniF677uniF678uniF679uniF67AuniF67BuniF67CuniF67DuniF67EuniF67FuniF680uniF681uniF682uniF683uniF684uniF685uniF686uniF687uniF688uniF689uniF68AuniF68BuniF68CuniF68DuniF68EuniF68FuniF690uniF691uniF692uniF693uniF694uniF695uniF696uniF697uniF698uniF699uniF69AuniF69BuniF69CuniF69DuniF69EuniF69FuniF6A0uniF6A1uniF6A2uniF6A3uniF6A4uniF6A5uniF6A6uniF6A7uniF6A8uniF6A9uniF6AAuniF6ABuniF6ACuniF6ADuniF6AEuniF6AFuniF6B0uniF6B1uniF6B2uniF6B3uniF6B4uniF6B5uniF6B6uniF6B7uniF6B8uniF6B9uniF6BAuniF6BBuniF6BCuniF6BDuniF633c_hc_kc_tf_bf_f_bf_f_hf_f_kf_f_tf_hf_jf_f_jf_kf_ts_puniFB06T_hlongs_blongs_hlongs_ilongs_klongs_llongs_longsuniFB05longs_longs_ilongs_longs_la.ende.endm.endn.endr.endK.altR.altk.altcaron.altcommaaccent.altpeseta.altAlphaiotasub.altAlphaiotasubasper.altAlphaiotasubasperacute.altAlphaiotasubaspergrave.altAlphaiotasubaspertilde.altAlphaiotasublenis.altAlphaiotasublenisacute.altAlphaiotasublenisgrave.altAlphaiotasublenistilde.altEtaiotasub.altEtaiotasubasper.altEtaiotasubasperacute.altEtaiotasubaspergrave.altEtaiotasubaspertilde.altEtaiotasublenis.altEtaiotasublenisacute.altEtaiotasublenisgrave.altEtaiotasublenistilde.altOmegaiotasub.altOmegaiotasubasper.altOmegaiotasubasperacute.altOmegaiotasubaspergrave.altOmegaiotasubaspertilde.altOmegaiotasublenis.altOmegaiotasublenisacute.altOmegaiotasublenisgrave.altOmegaiotasublenistilde.altEuro.fittedcent.fittedcolonmonetary.fitteddollar.fittedflorin.fittedfranc.fittedlira.fittednumbersign.fittedsterling.fittedyen.fittedEuro.oldstylecolonmonetary.oldstyleestimated.oldstyleflorin.oldstylefranc.oldstylelira.oldstylenumbersign.oldstylesterling.oldstyleyen.oldstylefranc.taboldstylelira.taboldstyleorn.001orn.002orn.003orn.004orn.005orn.006orn.007orn.008orn.009orn.010orn.011orn.012orn.013orn.014orn.015orn.016orn.017orn.018orn.019orn.020orn.021orn.022orn.023A.swashB.swashC.swashD.swashE.swashF.swashG.swashH.swashI.swashJ.swashK.swashL.swashM.swashN.swashO.swashP.swashQ.swashR.swashS.swashT.swashU.swashV.swashW.swashX.swashY.swashZ.swashT_h.swashAacute.swashAbreve.swashAcircumflex.swashAdieresis.swashAgrave.swashAmacron.swashAogonek.swashAring.swashAtilde.swashCacute.swashCcaron.swashCcedilla.swashCcircumflex.swashCdotaccent.swashDcaron.swashDcroat.swashEacute.swashEbreve.swashEcaron.swashEcircumflex.swashEdieresis.swashEdotaccent.swashEgrave.swashEmacron.swashEng.swashEogonek.swashGbreve.swashGcircumflex.swashGcommaaccent.swashGdotaccent.swashHbar.swashHcircumflex.swashIJ.swashIacute.swashIbreve.swashIcircumflex.swashIdieresis.swashIdotaccent.swashIgrave.swashImacron.swashIogonek.swashItilde.swashJcircumflex.swashKcommaaccent.swashLacute.swashLcaron.swashLcommaaccent.swashLdot.swashNacute.swashNcaron.swashNcommaaccent.swashNtilde.swashOacute.swashObreve.swashOcircumflex.swashOdieresis.swashOgrave.swashOhungarumlaut.swashOmacron.swashOslash.swashOslashacute.swashOtilde.swashRacute.swashRcaron.swashRcommaaccent.swashSacute.swashScaron.swashScedilla.swashScircumflex.swashScommaaccent.swashTbar.swashTcaron.swashTcommaaccent.swashT_h.caronswashT_h.commaaccentswashUacute.swashUbreve.swashUcircumflex.swashUdieresis.swashUgrave.swashUhungarumlaut.swashUmacron.swashUogonek.swashUring.swashUtilde.swashWacute.swashWcircumflex.swashWdieresis.swashWgrave.swashYacute.swashYcircumflex.swashYdieresis.swashYgrave.swashZacute.swashZcaron.swashZdotaccent.swashafii10056T_h.caronT_h.commaaccentafii10048afii10074afii10075afii10082afii10192afii10062afii10194afii10193afii10102afii10071afii10041afii10076afii10085afii10103afii10051afii10039afii10037afii10079afii10061afii10059afii10047afii10067afii10049afii10148afii10033afii10094afii10080afii10022afii10145afii10063afii10027afii10070afii10054afii10109afii10036afii10065afii10055afii10068afii10086afii10064afii10096afii10050afii10146afii10077afii10097afii10069afii10107afii10101afii10043afii10078afii10024afii10073afii10089afii10092afii10147afii10087afii10081afii10029afii10083afii10026afii10019afii10032afii10046afii10072afii10021afii10030afii10098afii10038afii10017afii10040afii10042afii10105afii10052afii10057afii10025afii10034afii10053afii10832afii10058afii10018afii10044afii10110afii10020afii10095Rholenisafii10104afii10106afii10090afii10091afii10060afii10028afii10045afii10099afii10066afii10084afii10031afii10196afii10035afii10088afii10093Eth.swashafii10100uni0394afii10023afii10195uni2215uni021Aafii10108uni03BCuni00ADuni00A0uni03A9uni021Bafii10846afii61352afii10831Copyright 2000 Adobe Systems Incorporated. All Rights Reserved. U.S. Patents Des. 338,907 and 371,799.Minion is either a registered trademark or a trademark of Adobe Systems Incorporated in the United States and/or other countries.Minion Pro ItalicMinion Proq N s ^mTw6zgjTRC @ q
C
d
m
r$7
,
Q
c
!*D )d Gcw~!;FJ3%3@FP8ir3y1S_ju(/6:n . 9 C v !!/!5!`!h!!!!!"""@"g"t"|""""###W#\#h#n#v######$$ $&$,$3$:$K$U$r$$$$$$$$$% %%%5%D%]%h%o%v%%%%%%%%%%%& &&,&9&C&J&P&U&j&&&&&&&&&&&''''#'(':'L'Q'\'a'g'x'''''''''(((%(/(7(>(E(L([(j(w(~((((((((((((((())))!).)9)D)K)R)Y)`)f)k)o)t))))))))))))))**
****%*0*;*F*Q*\*g*r*}*****-
oFl\8Mgk^?ŜeQ[a`FpUI߹|{{|VsrocghpzvL##4/Jcݹ+!MWagpu
|;;.|;9hꖧovgtfstqon@Sm|}ĬD⋄DQnJs8*Tlb~wg8`F(;@§ŰY9kde:S!VtVl-ܲq
m
ބ}A98}@=
^98ԏڒ,`fhMhx{r/S#Qݟ9ʞJ+^VT\]xZ]Rmh
dn$d_JoDO(q
zm
ӇbjVy-}EVeF4)AKڑף
ڄ|>[tA_d}ʟɩ藿ΎwC{LZnXH;slz`Z?; :\o"T÷ķT`ź_j{xR{YvPwUBy
|s^`_ZNu[XUoaN{;iV`VsjaK]<_IZF"v,
b|bw`tgigxumjbisˎA{lW_ïknruxutnivry?y>x? rxǼiwi4wxηŻ6xyppvTyJyQ,|;7
^1؟svmdؓd
upՆ]oXy.]#m
vu|YWx.^h~_tWpy^Fy_pp͆SVQL
owÐˑ_Dm
{qtg`O_Rxo|TpgC]cwxz8REpzD掚˴k[uqlchkmXfjevrkpocjfq~z~|zhfsPfnwr
Wym{qhlb\2\)FWy:y1er}yo;ڕԑZhĚڰW-Änj~sypkWkuo_8lewߢۂ|ogYQZktY00=ZH<4 Eu{tzy{|wB/`J
aoAh{1~Ug^YoG=E)?XEݻd9N9&)^:<>